How effective is the third dose and what it is really for – RB

How effective is the third dose and what it is really for – RB

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How effective is the third dose dose and what it really is for – RB

How effective is the third dose and what it really is – RB We have explained the details of the news, step by step, below. How effective is the third dose and what it really is – RB Keep reading our news. Here are all the details on the subject.

How effective is the third dose and what it really is – RB

It seemed by now that the idea is widespread that the third dose of vaccine protects little against the new Omicron variant , and that it is it is therefore necessary to do the fourth one, not long after (here the main symptoms of Omicron). In reality, the studies say in an increasingly evident way, it is true that over the months there is a reduction in the number of antibodies, but there is still a protection that lasts a very long time, “Definitely 9 months, but probably even more “.

To say this, also in the light of the new study on the fourth dose of the vaccine arriving from Israel, is the well-known director of the Institute of Pharmacological Research Mario Negri Giuseppe Remuzzi in an interview with “L’aria che tira” on La7. Remuzzi was among the very first in Italy, already at the beginning of the pandemic, to talk about the absolute need to treat Covid promptly, even from the very first symptoms, even apparently trivial, without waiting for the now famous “watchful wait” prescribed until a few days ago in the guidelines of the Ministry of Health.

How the third dose really works: Remuzzi’s explanation

In our organism we have memory cells, the so-called T lymphocytes, which remember they have already encountered the virus, and when they see the third dose they increase enormously in number, and their effectiveness in killing the virus increases, Remuzzi explains. “Therefore we must not interpret the third dose as an additional dose (even if for fragile subjects it is officially called that , ed), as if it did something more than what the first and second did “. The third dose does one thing that is qualitatively different : it intervenes on the answer in a whole new way. That’s why we won’t even need a fourth dose .

Fourth dose of vaccine yes or no?

The fourth dose will only be needed for frail people and certainly for organ transplant recipients , explains Remuzzi, who they are the people most exposed to the disease despite the 3 doses of vaccine. It has been seen that with the fourth dose even they can have an advantage, “but for them it always takes great attention from all of us”.

If we do too many close vaccines, is there really a risk that they will no longer have an effect ? The risk seems real. Taking the third dose and then after a few weeks even the fourth could be disadvantageous for our immune system.

“It’s true, especially if you take too close a dose,” he continues. The third dose, as for all other diseases that require three doses, must be done at a certain distance, “because the first two doses prepare the immune system, then the third triggers all the activities that are accessory but important and that need a preparation by the first two: for this, some time must pass between the two and the third “.

What changes for anti-Covid therapies

Remuzzi also returns to the point of anti-Covid cures , urged by Myrta Merlino. Finally a sentence of the Lazio TAR has effectively rejected the practice of “tachipirina and watchful waiting” .

The Tar, with a sentence published on 15 January 2022, ruled on an appeal filed by some doctors, who contested the validity of the circular of the Ministry of Health on the home management of patients with Covid infection, in the part in which, in the first days of the disease, it provides for the “vigilant waiting” and the administration of paracetamol (active ingredient of Tachipirina ) and in particular in the part in which it advised doctors against the use of certain drugs, such as hydroxychloroquine.

Advising against adopting certain treatments is contrary to the ethical code of doctors, says the ruling, which instead states that “the exercise of medicine is based on the freedom and independence of the profession, which constitute the inalienable right of the doctor” and provides in the Hippocratic oath “To practice medicine in freedom and independence of judgment and behavior”.

The ruling of the Lazio Regional Administrative Court says that the circular with the guidelines of Minister Speranza does not only impose “tachipirina and watchful waiting” and attention, because in any case it has not canceled this part, but only the one in which it advises doctors not to use certain drugs.

How to cure Covid from the very first symptoms , even when vaccinated

“From the very beginning, since February / March 2020 – explains Remuzzi – what we thought about doing before there were the tampons is treat Covid as we would treat any other upper respiratory tract infection , then with anti-inflammatory i, to avoid the evolution towards a hyper inflammatory syndrome that depends on an excess of stimulation of the immune system “: this is what leads to pneumonia, it’s not so much the virus that at some point, after the first 10 days, tends to go away.

Remuzzi and his team’s idea has always been not to lose the first 10 days with paracetamol and watchful waiting : “The first 10 days were lost, we do not ‘we have done”. However, although two papers have been published demonstrating a major reduction in the need for hospitalization with early use of anti-inflammatories, the working group has not yet come to produce such strong and flawless work as to persuade regulatory authorities to adopt this. approach.

“But doctors, since our two studies are published, after proper reviews, can read the literature and treat patients according to these indications,” he says. In fact, the activity of groups that deal with regulatory measures, which are called regulatory precisely because they have to comply with certain rules, must be distinguished with what is the activity of the doctor, who does not necessarily always have to follow the guidelines of the Ministry, ” but he can inquire and then make his decision “.

But how to cure Covid at the first symptoms, then? Not with tachipirina, as many doctors still do, but with anti-inflammatories, the so-called NSAIDs, which, as in any upper respiratory tract infection, block the virus (RB were among the first to talk about it and explain the home care provided by Prof. Remuzzi with the drugs to be taken immediately for the still initial and not serious cases ).